This website is intended for UK healthcare professionals only Log in | Register

Tag Archives: Lp-PLA 2 inhibitors

Targeting residual risk: a new approach to treating CVD?

July 2014 Br J Cardiol 2014;21:108–12 doi:10.5837/bjc.2014.023

Targeting residual risk: a new approach to treating CVD?

Alan Begg, Iain Findlay

Abstract

Introduction Atherosclerosis is a systemic disease of the large- and medium-sized muscular arteries, which is characterised by endothelial dysfunction, vascular inflammation, and the build up of lipids, cholesterol, calcium, and cellular debris within the intima of the vessel wall. This build up results in plaque formation, vascular remodelling, acute and chronic luminal obstruction, abnormalities of blood flow and diminished oxygen supply to target organs.1 Plaque rupture and thrombosis result in the acute clinical complications of atherosclerosis. The process of atherosclerosis begins early in life and progresses over many decades. Rupture

| Full text
Close

You are not logged in

You need to be a member to print this page.
Find out more about our membership benefits

Register Now Already a member? Login now
Close

You are not logged in

You need to be a member to download PDF's.
Find out more about our membership benefits

Register Now Already a member? Login now