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November 2009 Br J Cardiol 2009;16:269-71

NT-proBNP predicts atrial fibrillation

BJCardio editorial staff

Abstract

Reporting their findings (Circulation 2009;120:1768-74), a team led by Dr Kristen Patton (University of Washington, Seattle, US) conclude that: “Our results indicate a compelling, graded association between NT-proBNP levels and AF in a large, diverse cohort with extensive follow-up. The fact that elevated baseline NT-proBNP levels predict a diagnosis of AF even 16 years later suggests that peptide elevations precede the onset of arrhythmia,” they add. BNP, a neurohormone produced by the heart, regulates cardiac function and is widely used as a marker of heart failure. The precursor protein pro-B-type natriuretic peptide is cleaved to form

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