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Manage frailty effectively or manage decline – your choice and responsibility!

January 2019 Br J Cardiol 2019;26(1) doi:10.5837/bjc.2019.001 Online First

Manage frailty effectively or manage decline – your choice and responsibility!

Srikanth Bellary, Alan J Sinclair

Abstract

Frailty is strongly associated with cardiovascular disease (CVD) and, while the precise pathophysiological mechanisms linking frailty and CVD remain to be elucidated, it is likely that this association is bi-directional.4,6,7 Loss of muscle mass and function (sarcopaenia), insulin resistance and chronic low-level inflammation observed in the frailty state can predispose to CVD. On the other hand, the presence of CVD can lead to reduced activity, muscle loss and exhaustion, thus, predisposing to frailty. Large cross-sectional and longitudinal studies have shown that those with CVD were up to two to three times more likely to be frail than tho

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