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Tag Archives: simvastatin

March 2009 Br J Cardiol 2009;16:90–7

Efficacy and safety profile of co-administered ER niacin/laropiprant and simvastatin in dyslipidaemia

Gilbert Gleim, Christie M Ballantyne, Nancy Liu, Sally Thompson-Bell, Christine McCrary Sisk, Richard C Pasternak, Yale Mitchel, John F Paolini

Abstract

Introduction Large intervention studies suggest that while lowering low-density lipoprotein cholesterol (LDL-C) is beneficial, it is insufficient to prevent the majority of coronary heart disease (CHD) events. Niacin improves the overall lipid profile, LDL-C and triglycerides (TG) and is the most effective agent for raising high-density lipoprotein cholesterol (HDL-C) levels.1 Co-administration of niacin with a statin offers the potential for additional lipid management, but the use of niacin has been limited due to associated flushing, mediated primarily by prostaglandin D2 (PGD2).2 Flushing of the face and trunk occurs in nearly all patient

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November 2007 Br J Cardiol 2007;14:255-9

Scientific Sessions 2007 of the American Heart Association

BJCardio editorial team

Abstract

Prasugrel lowers events but increases bleeding compared with clopidogrel in PCI patients The new antiplatelet agent, prasugrel, reduced ischaemic events compared with clopidogrel but at the cost of an increase in major bleeding in the TRITON-TIMI 38 trial in acute coronary syndrome (ACS) patients scheduled for percutaneous coronary intervention (PCI). Overall mortality did not differ significantly between the two groups. In the study, which has also been published in the New England Journal of Medicine, prasugrel prevented 23 myocardial infarctions (MIs) for every 1,000 patients treated but caused an excess of six non-CABG (coronary artery by

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November 2006 Br J Cardiol 2006;13:386-90

News from the Scientific Sessions 2006 of the American Heart Association

BJCardio editorial team

Abstract

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