Tag Archives: stroke

Dual antiplatelet therapy for all CVD patients? Table 1. Currently used antiplatelet drugs Currently used antiplatelet drugs are summarised in table 1 and pivotal clinical trials of dual antiplatelet therapy in table 2. The Clopidogrel for High Atherothrombotic Risk and Ischaemia Stabilisation, Management and Avoidance (CHARISMA) trial2 is the only prospective randomised clinical trial to evaluate the efficacy and safety of dual antiplatelet therapy in all CVD patients. Initiated after the Clopidogrel versus Aspirin in Patients at Risk of Ischaemic Events (CAPRIE) trial had shown a 9% relative risk reduction with clopidogrel compared w

This new report from ECASS 3 was published online on October 21st in Lancet Neurology. The authors, led by Dr Werner Hacke (Ruprecht-Karls-Universität, Germany) report that although not all end points were statistically significant, there was “a clear pattern in favour of alteplase”. In the ECASS 3 trial, 821 stroke patients presenting 3-4.5 hours after symptom onset were randomised to alteplase (in the approved regimen of 0.9 mg/kg body weight) or placebo. The primary end point was disability at 90 days, and this was judged by a favourable or unfavourable outcome on the modified Rankin Scale. Results showed that significantly more pati

In this larger context, the international Reduction of Atherothrombosis for Continued Health (REACH) Registry was launched in order to study outcomes of atherothrombotic disease, risk factors for atherothrombosis, and also current treatment patterns. Already, the REACH Registry has provided insights at a global level.1 For example, under-treatment of common risk factors such as hypertension, hyperlipidaemia, and diabetes was observed in all regions included in the REACH Registry. Obesity, including morbid obesity, was highly prevalent. Multivascular disease – atherothrombosis affecting more than one arterial territory – was present in app

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