Tag Archives: systolic blood pressure

SPRINT, ESPRIT and BPROAD were three large RCTs with 9,361, 11,255 and 12,821 participants, respectively, that support a more intensive SBP target closer to 120 mmHg.5–7 These trials recruited patients ≥50 years old at high cardiovascular risk with SBP 130–180 mmHg.5–7 The primary composite outcome in all three trials focused on similar major cardiovascular outcomes: myocardial infarction, acute coronary syndrome not resulting in myocardial infarction, coronary or non-coronary revascularisation, stroke, decompensated heart failure or death from cardiovascular causes. The mean SBP achieved in SPRINT, ESPRIT and BPROAD trials (intensive

The latter study enrolled 9,361 participants, of whom 4,683 were randomised to a goal SBP of <140 mmHg, and 4,678 were randomised to a goal SBP of <120 mmHg, the latter defined as intensive blood-pressure lowering. During 5.2 years of follow-up, intensive SBP lowering was associated with a 26% lower risk of developing new-onset AF (hazard ratio 0.74, 95% confidence interval 0.56 to 0.98, p<0.037). This effect was consistent among prespecified subgroups of participants stratified by age and sex.2 It is salutary to note that patients aged 60 years and older who have a life-expectancy of >3 years also benefit from intensive SBP lower