A new stent which may promote healing of the artery better than currently available drug-eluting stents has shown promising results in initial clinical trials. The Genous Bio-engineered R StentTM, being developed by OrbusNeich, is coated with an antibody to capture a patient’s endothelial progenitor cells, which form a layer over the stent to provide protection against thrombus and minimise restenosis.
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In the current study, the GenousTM stent was associated with significantly fewer major adverse cardiac events (MACE) than the TaxusTMor CypherTM drug-eluting stents. The study, presented at the recent Italian Society of Invasive Cardiology by Dr Federico Piscione (Federico II University of Naples, Italy) involved 195 high-risk patients who received either a GenousTM, TaxusTM or CypherTM stent. Dual antiplatelet therapy was given for one month to the patients receiving a GenousTM stent and for nine months to those given one of the drug-eluting stents.
“GenousTM is a viable alternative to drug-eluting stents, which have raised many safety concerns among the interventional cardiology community,” Dr Piscione concluded.
A large phase III trial of the GenousTM stent is now underway.