What is aspirin resistance?

Br J Cardiol 2009;17(Suppl 1):S5-S7 Leave a comment
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Sponsorship Statement: The roundtable meeting was convened by the Aspirin Foundation and sponsored by Bayer HealthCare. The supplement was written by Steve Chaplin, a medical journalist. The speakers’, discussants’ and writer’s honoraria were met by the Aspirin Foundation. Production, printing and distribution of the supplement were sponsored by the Aspirin Foundation. The supplement was peer reviewed by the British Journal of Cardiology and approved by the faculty, Bayer HealthCare and the Aspirin Foundation. The Aspirin Foundation is supported by Bayer HealthCare and Reckitt Benckiser PLC.

Variable and sometimes ineffective drug treatment is not uncommon in the treatment of cardiovascular disease.(1) In most cases lack of patient compliance is the explanation but other reasons may also exist. In the case of aspirin, “low responsiveness” or “resistance” to aspirin in pharmacological terms would mean that the compound fails to reach its therapeutic goal, i.e. inhibition of platelet COX-1-dependent thromboxane formation. However, in vivo there might be also changes in platelet sensitivity or “residual” platelet activity independent of aspirin treatment, probably unrelated to the drug’s pharmacodynamic actions.(2)

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Disclaimer: UK prescribing information current at the date of publication of this supplement can be found by downloading the PDF. Medinews Cardiology Limited advises healthcare professionals to consult up-to-date Prescribing Information and the full Summary of Product Characteristics available from the manufacturers before prescribing any product. Medinews Cardiology Limited cannot accept responsibility for any errors in prescribing which may occur.