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Tag Archives: resistance

March 2010 Br J Cardiol 2009;17(Suppl 1):S8-S9

Aspirin – scope and limitations

Paul A Gurbel

Abstract

Identifying targets in the thrombosis pathway Figure 1. Central role of platelets and interaction with coagulation in the genesis of thrombosis (1) Figure 1 summarises the central role of platelets in the genesis of thrombosis.1 The platelet is initially activated in response to shear stress, events such as percutaneous coronary intervention (PCI) or plaque rupture, and the release of local agonists and exposure of the subendothelial components to flowing blood. Tissue factor ‘lights the fire’ by producing minute quantities of thrombin which then amplify the process. Binding of platelets to collagen and von Willebrand

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March 2010 Br J Cardiol 2009;17(Suppl 1):S5-S7

What is aspirin resistance?

Karsten Schrör

Abstract

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