Tag Archives: atherosclerosis

Risk calculation Dr Peter Brindle, the Research and Development Director and GP at the Bristol Primary Care Trust, lit the spark by taking the first lecture spot. With the title Advances and Controversies in CVD Risk Estimation he was stepping into the lions’ den. Earlier in the year H·E·A·R·T UK welcomed the continued use of well-established and validated risk calculation tools within the National Institute of Health and Clinical Excellence (NICE) lipid modification guideline and had endorsed the guideline group’s decision not to recommend more novel experimental approaches. So the delegates were keen to hear Dr Brindle announce the

Introduction Renal artery stenosis (RAS), traditionally the preserve of the nephrologist, is a condition of increasing interest to the cardiologist. Ninety per cent of RAS is caused by atherosclerosis and the risk factors for renal atherosclerosis and coronary atherosclerosis are the same. Furthermore, the presence of RAS alters the prognosis of co-existent cardiac disease, most notably cardiac failure and ischaemic heart disease, both directly1–3 and via its sequelae of renal failure and hypertension. Finally, the treatments for the disease, both medical and interventional, are familiar to the cardiologist, who can employ much of the knowl

ENHANCE controversy dominates meeting The controversial ENHANCE (Ezetimibe and Simvastatin in Hypercholesterolaemia Enhances Atherosclerosis Regression) trial of ezetimibe dominated the ACC meeting, with a special session held to discuss the results, which were simultaneously published in the New England Journal of Medicine. The 720-patient trial showed no benefit of ezetimibe when added to simvastatin 80 mg in slowing the progression of atherosclerosis in the carotid artery (as measured by intima media thickness (IMT) in patients with familial hypercholesterolemia (FH), despite the fact that there were significantly greater reductions in lo

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