Tag Archives: cardiovascular events

Introduction Chronic kidney disease (CKD) is a well-established risk factor for cardiovascular disease, associated with significantly increased morbidity and mortality.1 People with CKD often have multiple cardiovascular risk factors, including hypertension, diabetes mellitus and hyperlipidaemia. In addition to these traditional risk factors, CKD induces a pro-inflammatory state, which contributes to pathological myocardial remodelling, fibrosis, atherosclerosis and endothelial dysfunction. Further, associated disturbances in mineral metabolism including hyperphosphataemia and hyperparathyroidism lead to accelerated vascular calcification.2

The non-adherence problem Medication adherence is defined as the extent to which a patient acts in accordance with the prescribed interval and dose of a dosing regimen.1 Subsequently, non-adherence means that the patient is not taking all their medication doses as prescribed, jeopardising the clinical outcome. Cardiovascular medications (such as statins, antihypertensives and antithrombotics) remain the most commonly prescribed agents worldwide for both primary and secondary prevention of cardiovascular diseases (CVD). Patients with low adherence rates have a significantly greater risk of sustaining cardiovascular events compared to those wi

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