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Tag Archives: Immunotherapy

January 2020 Br J Cardiol 2020;27:19–23 doi:10.5837/bjc.2020.002 Online First

Cancer immunotherapy and its potential cardiac complications

Simon G Findlay, Ruth Plummer, Chris Plummer

Abstract

Introduction Immune checkpoint inhibitors (ICIs) have revolutionised outcomes in a number of advanced cancers. The median life-expectancy for patients with metastatic melanoma was nine months prior to the introduction of ICIs in 2011.1 One-year survival is now over 70%, and over half of patients are still alive at three years,2 with multiple phase II and III trials demonstrating durable responses in a range of tumour types.3 ICIs are antibodies that block the cytotoxic T-cell regulators lymphocyte-associated protein-4 (CTLA-4; ipilimumab), programmed cell death protein-1 (PD-1; nivolumab, pembrolizumab and cemiplimab) or the PD-1 ligand (ate

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