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Reperfusion, conditioning and the ongoing search for the holy grail

March 2017 Br J Cardiol 2017;24:35–8 doi:10.5837/bjc.2017.008

Reperfusion, conditioning and the ongoing search for the holy grail

Robert L Yellon, Rob M Bell

Abstract

Introduction Protecting the myocardium against lethal ischaemia necessitates rapid reperfusion. Paradoxically, however, reperfusion injures the myocardium, a phenomenon known as ‘ischaemia-reperfusion injury’ (IRI). There is currently no effective clinical intervention for IRI, in spite of the fact that it may contribute up to 50% of final myocardial infarct (MI) size.1 This review intends to describe past, present, and future clinical trials into ischaemic conditioning, which present one of the few avenues currently being explored clinically to kerb IRI. The principles of ischaemic conditioning and the supporting proof-of-concept studies

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