Tag Archives: coronary intervention

Introduction Unfractionated heparin (UFH) is a naturally occurring anticoagulant released from mast cells.1 It works by reversibly binding to antithrombin III (AT III) and accelerating the rate at which AT III inactivates the coagulation enzymes thrombin (factor IIa) and factor Xa. Since its discovery in 1916,2 UFH has been the most widely used anticoagulant for procedural or therapeutic indications.3 Percutaneous coronary intervention (PCI) inevitably causes vessel wall injury, which leads to activation of platelets and a localised vascular inflammatory reaction, which is prothrombotic and associated with an increased risk of acute or subacu

Introduction Arterial access through the transradial approach was described in the late 1980s.1 Radial approach in coronary interventions has advantages over the femoral approach with less vascular complications, less access site bleeding and earlier discharge post-procedure.2-4 In the PREVAIL (Prospective REgistry of Vascular Access in Interventions in Lazio region) study, patients who underwent coronary procedures through the radial artery had a statistically significant reduction in both major and minor bleeding (4.2% vs. 1.96%, p=0.03) and death or myocardial infarction (3.1% vs. 0.6%, p=0.005).5 Despite the multiple advantages of the tra

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