Tag Archives: diabetes

Aggressive risk factor modification: 30 year follow-up of IHD and non-haemorrhagic stroke Dear Sirs, In a single doctor’s practice in a high-risk area of South Sheffield, aggressive measures were taken to prevent ischaemic heart disease (IHD) and non-haemorrhagic stroke (ST) since 1980. Four cardinal risk factors were detected: smoking, diabetes, hypertension and cholesterol. Smoking, diabetes and hypertension were treated critically using standard guidelines and applying the latest evidence available independent of cost from 1980 onwards. Mortality from IHD has been known for many years to be directly related to the level of serum choleste

New drugs for diabetes A new DPP-4i for the management of type 2 diabetes, alogliptin (Vipidia®) has been launched by Takeda in the UK following data from EXAMINE, an outcome trial conducted in high risk acute coronary syndrome patients (see Br J Cardiol 2013;4:131) where the drug significantly reduced glucose levels and also demonstrated cardiovascular safety. Alogliptin and the fixed-dose combination product alogliptin and metformin (Vipdomet®) are now available in the UK. Alogliptin is licensed for the treatment of type 2 diabetes mellitus in adults aged 18 years and older to improve glycaemic control in combination with other glucose-lo

Caffeine intake may reduce risk of type 2 diabetes Coffee and caffeine intake may significantly reduce the incidence of type 2 diabetes, according to a new meta-analysis published in the European Journal of Clinical Nutrition.  Pertinent studies were identified by a search of PubMed and EMBASE. The fixed- or random-effect pooled measure was selected based on between-study heterogeneity. Dose–response relationship was assessed. Commenting on the implications of this study (doi: 10.1007/s00394-013-0603-x), London general practitioner Dr Sarah Jarvis said: “There is growing evidence to suggest that moderate coffee consumption, that’s four

Rather than a structured textbook this is a collection of individual essays, some of which are very useful and interesting, and some not quite so good. There are 38 contributors for 18 chapters. Compiled for doctors ranging from the internist to the specialist, it is very much an American text. Outside of the US it will arouse the curiosity of those of us interested in hypertension, more in terms of an insight into the current thoughts of our American cousins. One particular insight is the recommendation to do urine spot tests for sodium and potassium levels, to check adherence to the Dietary Approaches to Stop Hypertension (DASH) diet, with

FREEDOM: CABG beats PCI in diabetes patients with multi-vessel disease Coronary artery by-pass graft (CABG) surgery was associated with better outcomes than percutaneous coronary intervention (PCI) in patients with diabetes with multi-vessel coronary artery disease in the FREEDOM (Future Revascularization Evaluation in Patients With Diabetes Mellitus: Optimal Management of Multi-vessel Disease) trial. Senior FREEDOM investigator, Dr Valentin Fuster (Mount Sinai School of Medicine, New York, USA), said the results (table 1) would change practice. He estimated that patients in this study represent about a quarter of patients undergoing PCI. In

Introduction As doctors and scientists we are accustomed to breaking down problems and simplifying complex pathology in order to focus our management and identify possible targets for future therapies. The pathophysiology of cardiorenal disease is no different but, as yet, attempts to elucidate the complex interaction between heart and kidneys has failed. Although cardiac and renal disease are often diagnosed together, it is clear that a straightforward causal relationship does not exist. Disease in either serves as a risk factor for disease in the other and perpetuates the progression of that disease, but why this is so is unclear. Whilst th

CORONARY: off-pump and on-pump CABG similar The largest trial ever to compare off-pump and on-pump coronary artery bypass surgery (CABG) has shown no difference between the two techniques in terms of the primary composite end point. There were, however, some differences in certain end points, leading to the suggestion that the decision as to which approach to choose could be individualised with each patient. Table 1. Main results from the CORONARY trial The CORONARY trial enrolled 4,752 patients who were randomised to off-pump or on-pump surgery. At 30 days the primary end point – a composite of death, myocardial infraction (MI), kidney fai

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In the present study, researchers analysed data from the WHI on 153,840 post-menopausal women, of whom 7% were taking statins at baseline. During the study period, 10,242 incident cases of diabetes were reported. In an unadjusted risk model, statin use at baseline was associated with a 71% increased risk of diabetes, but after adjusting for other risk factors, this was reduced to a 48% increased risk. The association appeared to be a class effect. Risk was increased particularly in white, Hispanic, and Asian women, but not in African American women. The association was also observed at all levels of body mass index (BMI) but women with the lo

Introduction Treatment with insulin is essential for a good prognosis in patients with type 1 diabetes, and it is a potent hypoglycaemic agent in patients with type 2 diabetes. Insulin is an anabolic hormone that influences vascular tone in both large calibre conductance vessels and small calibre exchange vessels such as the capillary microcirculation.1,2 In view of the increased burden of cardiovascular disease in patients with diabetes, and the capability of insulin to influence both metabolic and vascular function, insulin therapy has the potential to improve prognosis from cardiovascular disease in patients with diabetes. The metabolic ef