Neurohormonal activation has a central role in the pathophysiology of various cardiovascular disorders. Despite recent therapeutic advances, potential exists to further manipulate these activated systems. The natriuretic peptide family consists of at least four structurally related peptides, with varying degrees of biological similarity. In the context of cardiovascular disease, the vast majority of data relates to atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP).
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