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Tag Archives: statins

February 2019 Br J Cardiol 2019;26:12

In brief

BJC Staff

Abstract

Non-inferior cardiovascular outcome for DPP-4 inhibitor Results from the CAROLINA cardiovascular outcome study show that the DPP-4 inhibitor linagliptin (Trajenta®, Boehringer Ingelheim and Eli Lilly) is non-inferior to the sulphonylurea glimepiride in the treatment of adults with type 2 diabetes and cardiovascular risk. The study met its primary end point – defined as the non-inferiority of linagliptin versus glimepiride in time to first occurrence of cardiovascular death, non-fatal myocardial infarction or non-fatal stroke. The study, carried out over six years in 6,033 adults with type 2 diabetes and increased cardiovascular risk or est

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November 2017 Br J Cardiol 2017;24:130

New series on insights from the Bradford Healthy Hearts project

BJC Staff

Abstract

The initiative was launched in February 2015 and in a relatively short period of time, the project achieved success in all three areas with measurable improvement in outcomes, including a reduction in hospitalisations. Over 24 months, there have been around 21,000 clinical interventions, with the emphasis being on delivering change at scale, whilst being fastidious about minimising any extra workload on primary care. In this period, 13,000 patients either started statins or had their statins changed, more than 1,000 patients with atrial fibrillation were anticoagulated, and more than 5,200 hypertensive patients reached a blood pressure targe

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October 2017

ESC 2017: REVEAL – modest beneficial effects with anacetrapib

BJC Staff

Abstract

Presented in a hotline session by Dr Martin Landray (University of Oxford), the trial’s co-principal investigator, and simultaneously published in the New England Journal of Medicine (https://doi.org/10.1056/NEJMoa1706444), this large-scale, placebo-controlled study was carried out on 30,449 patients with cardiovascular disease, who were all receiving lipid-lowering treatment with atorvastatin. Those patients also receiving anacetrapib (100 mg once daily) showed a significant reduction in the primary outcome, the risk of major coronary events (coronary death, myocardial infarction or coronary re-vascularisation) by 9% relative to those pati

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June 2017 Br J Cardiol 2017;24:47-8 doi:http://doi.org/10.5837/bjc.2017.014

A triumph of British cardiovascular medicine: “… and the last can be first…”

Adrian J B Brady

Abstract

The Gospel of Matthew tells us, “…the last can be first…” Nowhere is this truer than the towering UK success of that fundamental cornerstone of cardiovascular prevention, cholesterol-lowering therapy. In 2002, BJC published a paper showing how far the UK lagged behind other countries in Europe when it came to prescribing lipid-lowering drugs.1 At the same time, a number of other very large UK surveys were published.2 All showed that the UK was the sick man of Europe, with limited statin prescribing in the face of a huge burden of cardiovascular disease. Figure 1. Coronary heart disease (CHD) mortality compared to statin sales: Aug

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Statins and myalgia: fact or fiction?

October 2015 Br J Cardiol 2015;22:127–9 doi:10.5837/bjc.2015.033 Online First

Statins and myalgia: fact or fiction?

Peter Sever

Abstract

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Treatment patterns and lipid levels among patients with high-risk atherosclerotic CVD in the UK

October 2015 Br J Cardiol 2015;22:147–54 doi:10.5837/bjc.2015.034 Online First

Treatment patterns and lipid levels among patients with high-risk atherosclerotic CVD in the UK

Beth L Nordstrom, Jenna M Collins, Robert Donaldson, William A Engelman, Antje Tockhorn, Yajun Zhu, Zhenxiang Zhao

Abstract

Introduction Atherosclerotic cardiovascular disease (ASCVD), including peripheral arterial disease (PAD), coronary artery disease (CAD), acute coronary syndrome (ACS), and cerebrovascular disease (CeVAD), together account for approximately half of the morbidity and mortality in the adult population of Europe aged 50 years and older.1,2 The 2012 Coronary Heart Disease Statistics from the British Heart Foundation reported nearly 180,000 deaths in the UK from cardiovascular disease (CVD), 292 million prescriptions for CVD treatments, and over 87,000 percutaneous coronary interventions (PCIs) during a one-year span.3 In addition, diabetes mellitu

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August 2015 Br J Cardiol 2015;22:101–4 doi:10.5837/bjc.2015.029

Inflammation is associated with myocardial ischaemia

Kushal Pujara, Ashan Gunarathne, Anthony H Gershlick

Abstract

Introduction Coronary heart disease (CHD) is the leading cause of death worldwide. Chronic subclinical inflammation is a key recognised process in the pathogenesis of CHD, and may play an important role in atherogenesis. Figure 1. Atherosclerotic plaque rupture Atherosclerosis is a complex multi-factorial disease process, which is initiated at the endothelium in response to various forms of injurious stimuli (shear stress, oxidative stress, arterial pressure changes) including inflammation. These factors appear to alter the endothelial cell’s capacity to maintain homeostasis and vascular tone and leads to the so-called endothelial ‘dysfun

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September 2014 Br J Cardiol 2014;21:90

Correspondence: gender and outcome from acute myocardial infarction and secondary stroke

Professor Ivy Shiue; Dr Krasimira Hristova; Professor Jagdish Sharma

Abstract

Dear Sirs, Research on sex difference in mortality after myocardial infarction (MI) since the 1990s has been debated and increased. Several observational studies have shown that younger women, in particular, seemed to have higher mortality rates than men of similar age during the two-year or longer follow-up, although these studies were mainly from the USA.1-3 Recent American studies have also found that, even after full adjustment for potential risk factors, excess risk for in-hospital mortality for women was still noted, particularly among those <50 years old with acute ST-segment elevation MI, leading to 98% (odds ratio [OR] 1.98, 95% c

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New opportunities for cholesterol lowering: focus on PCSK9 inhibitors

July 2014 Br J Cardiol 2014;21:91–3 doi:10.5837/bjc.2014.021

New opportunities for cholesterol lowering: focus on PCSK9 inhibitors

Peter Sever, Judy Mackay

Abstract

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Hyperlipidaemia and monoclonal antibodies – paying for outcome

July 2014 Br J Cardiol 2014;21:94–5 doi:10.5837/bjc.2014.022

Hyperlipidaemia and monoclonal antibodies – paying for outcome

Gilbert Wagener

Abstract

Dr Gilbert Wagener (Transcrip Partners LLP) Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a new target for the treatment of hyperlipidaemia. PCSK9 is apparently complimentary to 3-hydroxy-3-methyl-glutaryl-CoA (HMG-CoA) reductase inhibition with statins.6,7 Most advanced in the development path are two monoclonal antibodies (mAbs) against PCSK9, alirocumab (SAR236533) and evolocumab (AMG145), both subcutaneous injectable drugs administered at bi-weekly or four-weekly intervals. Both compounds demonstrated solid reductions in LDL-C, however, dose selection for both focused on the most effective dose and did not consider titration ac

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