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Tag Archives: vitamin K antagonists

Unlocking the potential of NOACs

December 2014 Br J Cardiol 2014;21(suppl 2):S1–S7

Unlocking the potential of NOACs

Mr Sotiris Antoniou, Dr Chris Arden, Dr Jan Beyer-Westendorf, Dr David Hargroves, Dr Terry McCormack, Professor Gordon McInnes, Dr Raj Patel, Oliver Segal

Abstract

When the NOACs (novel oral anticoagulants) were introduced over three years ago, they promised to revitalise the management of conditions such as atrial fibrillation (AF), venous thromboembolism (VTE) and thromboprophylaxis after major joint replacement surgery. Rivaroxaban is currently available in multiple indications, including (but not limited to): prevention of stroke and systemic embolism in adult patients with non-valvular AF, treatment of deep vein thrombosis (DVT) and pulmonary embolism (PE), and the prevention of recurrent DVT and PE in adults. For decades anticoagulant therapy in these conditions had relied on the vitamin K antagon

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Rivaroxaban in non-valvular AF – UK experience in perspective

September 2014 Br J Cardiol 2014;21(suppl 1):S1–S11

Rivaroxaban in non-valvular AF – UK experience in perspective

Diana A Gorog

Abstract

ESC guidelines and differences between NOACs Following the roll-out of the novel oral anticoagulants (NOACs), the European Society of Cardiology (ESC) published in 2012 a focused update of its guidelines for the management of atrial fibrillation (AF). Since the NOACs tested in clinical trials all showed at least non-inferiority when compared with vitamin K antagonists (VKAs), with a better safety profile, particularly with reduction in intracranial haemorrhage (ICH), the ESC 2012 guideline recommended NOACs as broadly preferable to VKAs in the vast majority of patients with non-valvular AF (NVAF).1 In 2013, the European Heart Rhythm Associati

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Rivaroxaban in non-valvular AF – French experience in perspective

September 2014 Br J Cardiol 2014;21(suppl 1):S1–S11

Rivaroxaban in non-valvular AF – French experience in perspective

Laurent Fauchier, Edouard Siméon, Christophe Saint-Etienne

Abstract

Introduction Vitamin K antagonists (VKAs) reduce the risk of stroke in patients with atrial fibrillation (AF). For more than five decades, they were the only available treatment. Novel oral anticoagulants (NOACs) have recently been approved for the prevention of non-valvular AF-related stroke. Dose-adjusted VKA therapy and NOACs are highly effective in AF patients. However, dabigatran, rivaroxaban and apixaban are more convenient, while at least equally effective and with a comparable safety profile (regarding bleeding complications) for stroke prevention compared with VKAs.1-3 Recent guidelines prefer treatment with NOACs over VKAs for most

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Novel oral anticoagulants in daily clinical practice – German experience with rivaroxaban

September 2014 Br J Cardiol 2014;21(suppl 1):S1–S11

Novel oral anticoagulants in daily clinical practice – German experience with rivaroxaban

Ingo Ahrens, Christoph Bode

Abstract

Summary Oral anticoagulation has been restricted to vitamin K antagonists (VKAs) for more than 50 years. Starting in the last decade of the past century, central coagulation factors such as thrombin and factor Xa were explored as potential targets for the development of novel oral anticoagulants (NOACs). This led to the successful development and approval of a novel class of direct oral anticoagulants targeting factor Xa. Rivaroxaban was the first of the novel class of agents named ‘xabans’ that are direct oral factor Xa inhibitors. Since its initial approval for thromboembolic prophylaxis after hip and knee surgery in 2008, rivaroxaban a

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